Z., Zuberi, M. H., and Siddiqui, F. A. B. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. Pharmaceutical Biology (Netherlands). Akhondian, J., Parsa, A., and Rakhshande, H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. 2014 Feb;5(2):210-16. 1998;53(2):87-93. Early research shows that taking black seed oil improves pain and stiffness in people with RA who are already taking methotrexate. Cell Physiol Biochem. Boskabady, M. H., Mohsenpoor, N., and Takaloo, L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Mouhajir F and et al. 1985;35(1A):408-414. Effect of black cumin (Nigella sativa) on cadmium-induced oxidative stress in the blood of rats. Int J Oncol. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. 2. Some people apply black seed directly to the skin for joint pain (rheumatism), headache, and certain skin conditions. Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Obesity. Toxicology 3-7-2000;143(3):219-226. 10-30-2009;2(4-5):163-172. High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Aljabre, S. H., Randhawa, M. A., Alakloby, O. M., and Alzahrani, A. J. Thymoquinone inhibits germination of dermatophyte arthrospores. American Journal of Applied Sciences. Effect of dexamethasone and Nigella sativa on peripheral blood eosinophil count, IgG1 and IgG2a, cytokine profiles and lung inflammation in murine model of allergic asthma. 2014;152(1):156-62. Phytother.Res. J Oleo.Sci 2008;57(3):171-179. J Ethnopharmacol 1996;52:23-6. 2004;18(4):280-284. Tuna HI, Babadag B, Ozkaraman A, Balci Alparslan G. Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric individuals. View abstract. Landa, P., Kokoska, L., Pribylova, M., Vanek, T., and Marsik, P. In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E(2) biosynthesis. View abstract. Phytother Res 2012;26:1246-8. Antimicrobial thymohydroquinones of Moroccan Nigella sativa seeds detected by electron spin resonance. View abstract. Kamal EH and et al. View abstract. Gali-Muhtasib, H., Kuester, D., Mawrin, C., Bajbouj, K., Diestel, A., Ocker, M., Habold, C., Foltzer-Jourdainne, C., Schoenfeld, P., Peters, B., Diab-Assaf, M., Pommrich, U., Itani, W., Lippert, H., Roessner, A., and Schneider-Stock, R. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. Hassan SA and et al. 1997;5:110-113. J.Egypt.Med.Assoc. Eur J Cancer Prev 1999;8:435-40. View abstract. 2009;6(8):1440-1447. Juhas, S., Cikos, S., Czikkova, S., Vesela, J., Il'kova, G., Hajek, T., Domaracka, K., Domaracky, M., Bujnakova, D., Rehak, P., and Koppel, J. El Hissy, F. T., Abdel-Hafez, S. I., and Abdel-Kader, M. I. Rhizosphere fungi of five plants in Egypt. Effects of Nigella sativa and Lepidium sativum on Effect of herbal melanin on IL-8: a possible role of Toll-like receptor 4 (TLR4). View abstract. 2001;110(5-6):333-345. Chem.Biodivers. Also, you can use black seeds for healing diarrhea, constipation, gas, hemorrhoids, flu, bronchitis, cough, allergies, asthma, high blood pressure, menstruation, high cholesterol, etc. View abstract. Biol.Trace Elem.Res 2006;110(2):151-162. 2007;21(5):559-566. Biomed.Sci Instrum. Gen.Pharmacol. Asgari S and et al. Phytochem.Anal. Badary, O. Complement Ther Med 2019;45:149-55. View abstract. 2001;110(5-6):333-345. Erdurmus, M., Yagci, R., Yilmaz, B., Hepsen, I. F., Turkmen, C., Aydin, B., and Karadag, R. Inhibitory effects of topical thymoquinone on corneal neovascularization. How Long Does Coronavirus Live On Surfaces? Help About Diabetes Problems J Ayub.Med Coll.Abbottabad. J Ethnopharmacol. My Thoughts: If you have thyroid problems, get your TSH and thyroid auto-antibodies tested first. View abstract. Early research shows that taking black seed extract by mouth reduces the number of seizures in children with epilepsy. Other uses include lowering blood pressure, lowering cholesterol levels, treating cancer, and boosting the immune system. 2004;279(1):685-691. 2008;20(2):118-124. View abstract. Norton. Morikawa, T., Xu, F., Ninomiya, K., Matsuda, H., and Yoshikawa, M. Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin. Arch Toxicol. Soleymani S, Zargaran A, Farzaei MH, et al. Basic Clin Pharmacol.Toxicol. View abstract. View abstract. Saudi J Kidney Dis Transpl. View abstract. Ann Saudi Med 2017;37:56-63. Hanafy MS, Hatem ME. J Ethnopharmacol. 2005;17(2):72-74. View abstract. 2009;47:77-80. Regulation of Low-Density Lipoprotein Receptor and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene Expression by Thymoquinone-Rich Fraction and Thymoquinone in HepG2 Cells. Landa, P., Marsik, P., Havlik, J., Kloucek, P., Vanek, T., and Kokoska, L. Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species. Pharmaceutical Biology (Netherlands). Al Awadi, F. M. and Gumaa, K. A. Ahmad Alobaidi AH. 11-19-2003;51(24):6961-6969. View abstract. A. and Gamal el-Din, A. M. Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Planta Med 2008;74(11):1403-1405. Mansour, M. A., Ginawi, O. T., El Hadiyah, T., El Khatib, A. S., Al Shabanah, O. A., Al Sawaf, H. A., Al Sohaibani, M. O., and Al Bekairi, A. M. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Isik H, Cevikbas A, GÃ¼rer US, et al. J Physiol Pharmacol. El Wakil, S. S. Evaluation of the in vitro effect of Nigella sativa aqueous extract on Blastocystis hominis isolates. View abstract. Ragheb, A., Attia, A., Elbarbry, F., Prasad, K., and Shoker, A. Attenuated Combined Action of Cyclosporine A and Hyperlipidemia on Atherogenesis in Rabbits by Thymoquinone. 2006;80(11):768-776. Suboh, S. M., Bilto, Y. Y., and Aburjai, T. A. View abstract. Akhtar MS, Riffat S. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. A. Proximate analysis and fatty acid composition of Nigella sativa (Kalonji) seed oil growing in Pakistan. View abstract. Folia Microbiol. HPB (Oxford) 2009;11(5):373-381. Tan, M., Norwood, A., May, M., Tucci, M., and Benghuzzi, H. Effects of (-)epigallocatechin gallate and thymoquinone on proliferation of a PANC-1 cell line in culture. Mansour, M. and Tornhamre, S. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. Gali-Muhtasib, H., Ocker, M., Kuester, D., Krueger, S., El Hajj, Z., Diestel, A., Evert, M., El Najjar, N., Peters, B., Jurjus, A., Roessner, A., and Schneider-Stock, R. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. Contact Dermatitis 1997;36(5):268-269. View abstract. View abstract. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Black seed oil and perioperative serotonin syndrome: A case report. Z.Allg.Mikrobiol. Kocyigit, Y., Atamer, Y., and Uysal, E. The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats. View abstract. View abstract. View abstract. Effect of Nigella sativa on blood hemostatic function in rats. Salem EM, Yar T, Bamosa AO, et al. View abstract. Historically, black seeds are used for treating intestinal worms, nasal congestion, toothache, headache, and parasites. al Awadi, F., Fatania, H., and Shamte, U. View abstract. Herba Polonica (Poland). View abstract. Phytother.Res. Saudi Med J 2007;28(11):1654-1657. View abstract. View abstract. Research shows that taking black seed by mouth along with asthma medicines can improve coughing, wheezing, and lung function in some people with asthma. 2009;7(1):9. Cancer Res. Pharmacol Res. Some cardiovascular effects of the dethymoquinonated Nigella sativa volatile oil and its major components alpha-pinene and p-cymene in rats. 2000;22(9):729-740. View abstract. View abstract. Potential hepatoprotective effects of vitamin E and Nigella sativa oil on hepatotoxicity induced by chronic exposure to malathion in human and male albino rats. Toppozada, H. H., Mazloum, H. A., and el Dakhakhny, M. The antibacterial properties of the Nigella sativa l. seeds. Tangyuenyongwatana, P., Kowapradit, J., Opanasopit, P., and Gritsanapan, W. Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa. 2003;39:359-364. View abstract. View abstract. A., Al Sawaf, H. A., Al Sohaibani, M. O., and Al Bekairi, A. M. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. A. Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Mol.Cancer Res 2008;6(6):1059-1070. Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic beta-cells, skeletal muscle cells, and adipocytes. View abstract. Bin Sayeed MS, Shams T, Fahim Hossain S, et al. View abstract. Res Vet.Sci 2010;88(3):400-404. Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Effects of thymoquinone, the major constituent of Nigella sativa seeds, on the contractile responses of rat vas deferens. Abu-Al-Basal MA. 2009;55:109-125. Eur.J Gastroenterol.Hepatol. Therefore, you may wonder whether eating black sesame seeds is also good for hair and skin health. Neurochem.Res 2008;33(3):579-588. View abstract. specific immunotherapy in allergic rhinitis patients. 2002;79(1):1-11. Toxicol Lett 1998;95:23-9. View abstract. Osteoarthritis. Saudi Med J 2009;30(3):443-445. 2006;44(9):745-748. Other research shows that taking both crushed black seed and garlic oil in addition to other products that lower cholesterol, such as simvastatin, can lead to larger improvements in blood cholesterol and triglyceride levels than simvastatin alone. 2005;12(1-2):100-107. View abstract. Historically, black seed has been used for headache, toothache, nasal congestion, and intestinal worms.It has also been used for “pink eye” (conjunctivitis), pockets of infection (abscesses), and parasites. Phytother.Res 2003;17(8):942-946. Black seed might also improve levels of cholesterol in people with diabetes. Hamdy, N. M. and Taha, R. A. J Ethnopharmacol. View abstract. 8-15-2007;67(16):7782-7788. Endocrine. Biomed.Sci Instrum. BY MOUTH: Did you or will you purchase this product in-store or online? McDermott, C., O'Donoghue, M. H., and Heffron, J. J. n-Hexane toxicity in Jurkat T-cells is mediated by reactive oxygen species. Complement Ther Clin Pract 2018;31:290-4. doi: 10.1016/j.ctcp.2018.03.013. J Ethnopharmacol. View abstract. View abstract. Aggarwal, B. Ren Fail. Ravindran, J., Nair, H. B., Sung, B., Prasad, S., Tekmal, R. R., and Aggarwal, B. Sahebkar A, Soranna D, Liu X, et al. J Ethnopharmacol. View abstract. B., Harikumar, K. B., Tharakan, S. T., Sung, B., and Anand, P. Potential of spice-derived phytochemicals for cancer prevention. 2018;38:48-57. Int J Cardiol. View abstract. View abstract. Early research shows that using a nasal spray containing black seed oil can reduce dryness, blockage, and crusting of the nostrils in elderly patients with nasal irritation. 2006;42:464-469. Therapeutic value of black seed oil in methotrexate hepatotoxicity in Egyptian children with acute lymphoblastic leukemia. Toxicological & Environmental Chemistry. 1-30-2009;121(3):419-424. International Journal of Pharmacognosy (Netherlands). Badar A, Kaatabi H, Bamosa A, et al. View abstract. Koshak A, Wei L, Koshak E, et al. Tangyuenyongwatana, P. and Gritsanapan, W. A study on artifacts formation in the Thai traditional medicine Prasaplai. Alam MA, Nasiruddin M, Haque SF, Khan RA. View abstract. Ali, Z., Ferreira, D., Carvalho, P., Avery, M. A., and Khan, I. Ebru, U., Burak, U., Yusuf, S., Reyhan, B., Arif, K., Faruk, T. H., Emin, M., Aydin, K., Atilla, I. I., Semsettin, S., and Kemal, E. Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats. Gynecol Endocrinol. Kanter, M. Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations. 2004;40:111-116. A., Ali, B. Some early research shows that taking crushed black seed increases "good" high-density lipoprotein (HDL) cholesterol and reduces total cholesterol, "bad" low-density lipoprotein (LDL) cholesterol, and blood fats called triglycerides in people with borderline high cholesterol. View abstract. Nagi MN, Alam K, Badary OA, et al. Moustafa HAM, El Wakeel LM, Halawa MR, Sabri NA, El-Bahy AZ, Singab AN. El Gazzar, M. A. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. New Chapter/Fermented Black Seed Booster Powder ($18.91/ounce) New Chapter also offers a Fermented Black Seed Booster Powder, specially designed for mental acuity and mood. Effect of nigella sativa and allium sativum coadministered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial. View abstract. Meral, I. and Kanter, M. Effects of Nigella sativa L. and Urtica dioica L. on selected mineral status and hematological values in CCl4-treated rats. Al Naqeep, G., Ismail, M., and Allaudin, Z. Research shows that taking black seed by mouth might reduce blood pressure by a small amount. A., Randhawa, M. A., and Shaikh, N. A. Planta Med 2001;67(1):29-32. Edris, A. E. Anti-cancer properties of Nigella spp. Urol.J 2007;4(2):86-90. J Ethnopharmacol 1991;31:283-9. Chaubey, M. K. Fumigant toxicity of essential oils from some common spices against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae). Planta Med 1995;61:33-6. Fararh, K. M., Ibrahim, A. K., and Elsonosy, Y. Arch Toxicol. Mutabagani A and et al. 2008;14(3):128-134. View abstract. By increasing the immune system, black seed might decrease the effectiveness of medications that decrease the immune system. View abstract. 11-1-1999;67(2):135-142. View abstract. View abstract. Diabetes: Black seed might lower blood sugar levels in some people. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. 2008;44:477-482. © 2005 - 2019 WebMD LLC. View abstract. Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats. Le, P. M., Benhaddou-Andaloussi, A., Elimadi, A., Settaf, A., Cherrah, Y., and Haddad, P. S. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. seed on memory, attention and cognition in healthy human volunteers. Mahdy KA and et al. A., Abdel-Naim, A. View abstract. Res Commun.Mol.Pathol.Pharmacol. View abstract. Saudi J Gastroenterol. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Early research suggests that taking black seed oil by mouth might improve symptoms in people with itchy and inflamed skin. Ismail, M., Al Naqeep, G., and Chan, K. W. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. View abstract. Arzneimittelforschung. 2008;44:465-470. 2007;37(3):801-813. A., El Kady, M. B., Nemat, F. M., and Morsy, M. E. A novel approach for the management of the chalkbrood disease infesting honeybee Apis mellifera L. (Hymenoptera: Apidae) colonies in Egypt. View abstract. Massadeh, A. M., Al Safi, S. A., Momani, I. F., Al Mahmoud, M., and Alkofahi, A. S. Analysis of cadmium and lead in mice organs: effect of Nigella sativa L. (Black Cumin) on the distribution and immunosuppressive effect of cadmium-lead mixture in mice. Benhaddou-Andaloussi A and et al. Dahri, A. H., Chandiol, A. M., Rahoo, A. View abstract. 2010;32(2):284-296. Electron Physician. 2002;46(2):195-201. A., Nagi, M. N., Al Shabanah, O. Cancer Detect.Prev. Vance, S. H., Benghuzzi, H., Wilson-Simpson, F., and Tucci, M. Thymoquinone supplementation and its effect on kidney tubule epithelial cells in vitro. Ann.Saudi Med 2001;21(3-4):242-244. People have used the seed to make medicine for over 2000 years. Dermatol Ther 2019;32(4):e12949. J Pak.Med Assoc. Taking black seed along with medications that also slow blood clotting might increase the chances of bruising and bleeding. View abstract. 2009;35(3):344-349. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol 2018;219:173-81. doi: 10.1016/j.jep.2018.03.001. 2008;23(7):2206-2212. View abstract. Rafati M, Ghasemi A, Saeedi M, et al. BMC.Pharmacol. Auris Nasus Larynx. View abstract. Internet Journal of Nutrition & Wellness (INTERNET J NUTR WELLNESS). 2002;46(2):195-201. Phytother.Res 2004;18(3):195-199. Salomi NJ, Nair SC, Jayawardhanan KK, et al. Biomed.Sci.Instrum. Indigestion (dyspepsia). Free Radic.Res 2007;41(2):153-161. Dtsch.Tierarztl.Wochenschr. View abstract. J Appl.Toxicol. Takada, M. On the metabolic detoxication of 4-iodothymol in man. View abstract. 2004;19(5):431-436. View abstract. Zaoui, A., Cherrah, Y., Mahassini, N., Alaoui, K., Amarouch, H., and Hassar, M. Acute and chronic toxicity of Nigella sativa fixed oil. Acta Histochem. Saudi J Kidney Dis.Transpl. Nephrol.Dial.Transplant. View abstract. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Arch Pharm.Res 2009;32(1):75-78. Black seed oil is a highly concentrated oil that is derived from black cumin seeds, which also go by the name black caraway seeds and fennel flower, among others. Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. J Ethnopharmacol. A., Badary, O. Kacem, R. and Meraihi, Z. 2007;13(12):CR555-CR559. Toxicology 3-7-2000;143(3):219-226. View abstract.
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